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KMID : 1134820230520020138
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Journal of the Korean Society of Food Science and Nutrition
2023 Volume.52 No. 2 p.138 ~ p.145
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Effects of AP Collagen Peptides on Extracellular Matrix Protein Production and Skin Density
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Jung Kyoung-Mi
Chae Min-Jung
Kim Seung-Hun
Kim A-Reum
Lim Seong-Hwan
Moon Chang-Yong
Roh Jong-Hwa
Kim Wan-Gi
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Abstract
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Skin aging is characterized by structural changes in dermal extracellular matrix (ECM) due to continuous exposure to internal and external factors like oxidative stress. The purpose of this study was to examine the effect of AP collagen peptide (APCP) on ECM changes induced by hydrogen peroxide (H2O2)-oxidative stress in a human dermal fibroblast model and on skin density and skin wrinkling in middle-aged women. APCP effectively recovered H2O2-induced reductions in cell viability. H2O2 stimulation significantly downregulated the gene expressions of COL1A, elastin, and fibronectin, which were dose-dependently restored by APCP. Sixty-eight women aged 35 to 60 with crow’s feet wrinkles were evaluated in this double-blind, randomized, placebo-controlled study to investigate the effects of orally administered APCP on skin density and wrinkles. Subjects took APCP 1,500 mg or a placebo once daily for 12 weeks. The APCP group significantly improved skin density and crow’s feet wrinkles, as determined by Ra, Rmax, Rp, and Rz values, compared to the placebo group and had similar effects on marionette line wrinkles. This study shows that orally administered APCP promotes ECM protein production in skin fibroblasts and suggests that APCP has potential as a functional food ingredient that ameliorates skin density and skin wrinkles.
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KEYWORD
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AP collagen peptide, skin density, skin wrinkles, extracellular matrix, oxidative stress
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